Acute intraoperative tumour lysis syndrome

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Case report: acute tumour lysis syndrome.

INTRODUCTION Acute tumour lysis syndrome (ATLS) is a potentially lethal but preventable complication of oncological treatment. CLINICAL PICTURE We report a case of a patient with Burkitt's leukaemia who developed ATLS after treatment with chemotherapy. TREATMENT Standard preventive measures using aggressive hydration, urine alkalinisation and uricosuric agents were instituted before chemoth...

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Tumour lysis syndrome: implications for cancer therapy.

The tumour lysis syndrome (TLS) is a group of metabolic abnormalities caused by rapid and unexpected release of cellular components into the circulation as a result of massive destruction of rapidly proliferating malignant cells. It usually develops in patients with hematologic malignancies like acute lymphoid leukemia, non-Hodgkin and Burkitt's lymphoma after initiation of chemotherapy or may,...

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Radiation induced tumour lysis syndrome in a patient with leukaemia.

Tumour lysis syndrome is a catastrophic complicalion of treatment of certain neoplasms. It is usually seen with the tumours that have high growth fractions, increased bulk and extreme sensitivity to cytotoxic therapy. Most commonly it occurs in association with hematologic malignancies such as lymphomas and leukaemias. Rarely it has been observed with solid tumours like small cell lung cancer, ...

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Spontaneous Tumour Lysis Syndrome in a Multiple Myeloma

The tumor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur in consequence of the release of intracellular contents following lysis of tumor cells. TLS occurs spontaneously or after chemotherapy. Spontaneous TLS is uncommon occurrence in multiple myeloma (MM). We define a case of a 70-year-old woman patient who was found to have MM with spontaneous TLS, following a comp...

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Tumour lysis syndrome (TLS) is caused by the disintegration of malignant cells, usually following the instigation of chemotherapy, although it may already be established at the time of initial presentation in a minority of cases. As a direct consequence of malignant cell breakdown, intracellular ions, proteins, nucleic acids and their metabolites are released into the plasma causing the charact...

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ژورنال

عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie

سال: 2010

ISSN: 0832-610X,1496-8975

DOI: 10.1007/s12630-010-9357-6